LL37 (5mg)

Description

Product: LL37 (5mg) Product Overview: LL37 is a synthetic peptide derived from the human cathelicidin antimicrobial peptide precursor, hCAP18. Composed of 37 amino acids, it adopts an alpha-helical structure and is classified as a cationic amphipathic peptide. LL37 has been investigated for its potential roles in innate immunity and cellular signaling pathways, making it a focus of interest in various research fields. Research Profile: LL37 has been studied for its diverse biological activities, particularly in the context of host defense mechanisms and cellular interactions. Research has explored its molecular pathways and interactions, including: - Antimicrobial Activity: Investigated for its ability to interact with microbial membranes and potentially disrupt their integrity via charge-based interactions and pore formation in vitro. - Immune Modulation: Studied for its potential to influence inflammatory responses by interacting with Toll-like receptors (TLRs) and affecting cytokine production in preclinical models. - Cellular Proliferation and Migration: Examined in research models for its potential involvement in wound-related cellular processes, including effects on growth factors and matrix metalloproteinases. - Apoptotic Processes: Investigated in preclinical studies for its potential effects on programmed cell death pathways in specific cellular contexts. - Host-Pathogen Interactions: Studied for its ability to bind bacterial components, such as lipopolysaccharides (LPS), which may influence pathogen virulence and immune recognition in research models. Key Research Applications: LL37 is utilized in laboratory research to better understand its biological functions and molecular mechanisms. Key areas of investigation include: - Infectious Disease Research: Examination of LL37’s antimicrobial properties against bacterial, viral, and fungal agents in vitro. - Immunology Studies: Research into its potential role in modulating innate and adaptive immune responses, particularly through interactions with TLR signaling pathways. - Wound Healing Research: Investigated for its potential to promote keratinocyte migration and proliferation, as well as its interactions with extracellular matrix components in preclinical models. - Cancer Biology: Studied in research exploring LL37’s effects on tumor microenvironment dynamics and its potential involvement in apoptotic processes. Specifications: Peptide Content: 5 mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls.